Aminopterin - CISMeF

Preferred Label : Aminopterin;

NCIt synonyms : 4-Amino-PGA; 4-Aminopteroylglutamic Acid; Aminopteroylglutamic Acid; 4-Aminopteroyl-glutamic Acid;

NCIt related terms : APGA; 4-Aminofolic acid;

NCIt definition : A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antimetabolites.;

UNII : JYB41CTM2Q;

InChIKey : TVZGACDUOSZQKY-LBPRGKRZSA-N;

CAS number : 54-62-6;

Chemical formula : C19H20N8O5;

NSC code : 739;

ChEBI ID : CHEBI:22526;

Codes from synonyms : CDR0000045171; 02633; NSC0000739; 29;

Details

Origin ID

C235;

UMLS CUI

C0002583;

Automatic exact mappings (from CISMeF team)
- Apgar [LOINC method]
Currated CISMeF NLP mapping
- aminopterin [MeSH Descriptor]
- aminopterin [MeSH concept]
- aminopterin [SNOMED Notion]
- n-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-l-glutamic acid [Substance BNPC]
False automatic mappings
- Aminopterin (substance) [SNOMED CT concept]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Aminopterin (substance) [SNOMED CT concept]
- aminopterin [MeSH concept]
- aminopterin [MeSH Descriptor]
- aminopterin [SNOMED Notion]
- n-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-l-glutamic acid [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Aminopterin Sodium [NCIt concept]
is_component_of_chemotherapy_regimen
- Aminopterin/Leucovorin Calcium [NCIt concept]
is_free_acid_or_base_form_of
- Aminopterin Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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