" /> Aminopterin - CISMeF





Preferred Label : Aminopterin;

NCIt synonyms : 4-Amino-PGA; 4-Aminopteroylglutamic Acid; Aminopteroylglutamic Acid; 4-Aminopteroyl-glutamic Acid;

NCIt related terms : APGA; 4-Aminofolic acid;

NCIt definition : A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antimetabolites.;

UNII : JYB41CTM2Q;

InChIKey : TVZGACDUOSZQKY-LBPRGKRZSA-N;

CAS number : 54-62-6;

Chemical formula : C19H20N8O5;

NSC code : 739;

ChEBI ID : CHEBI:22526;

Codes from synonyms : CDR0000045171; 02633; NSC0000739; 29;

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28/07/2025


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