Phosphatidylinositol

Preferred Label : Phosphatidylinositol;

NCIt synonyms : PI;

NCIt definition : A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide. It is a very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo inositol linked through the 1 hydroxyl group to phosphatidic acid. The 4 phosphate (PIP) and 4, 5 bisphosphate derivatives PIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles). Signal sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5 triphosphate (Ins P3: IP3). Both the diacyl glycerol and products act as second messengers.;

ChEBI ID : CHEBI:28874;

Details

Origin ID

C743;

UMLS CUI

C0031621;

Automatic exact mappings (from CISMeF team)
- Greek letter pi (qualifier value) [SNOMED CT concept]
- Perfusion Index [MeSH Descriptor]
- Phosphatidyl inositol (substance) [SNOMED CT concept]
- Serpin peptidase inhibitor, clade a, member 1 [OMIM gene]
- gamma-aminobutyric acid type A receptor subunit pi [HGNC gene]
- phosphatidyl inositol [SNOMED Notion]
- pineal body [UBERON concept]
- serpin family A member 1 [ORDO Gene]
Currated CISMeF NLP mapping
- Phosphatidylinositol [FMA entity]
- Phosphatidylinositol [LOINC component]
- phosphatidylinositols [MeSH Descriptor]
- phosphatidylinositols [MeSH concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Phosphatidyl inositol (substance) [SNOMED CT concept]
- Phosphatidylinositol [FMA entity]
- Phosphatidylinositol [LOINC component]
- phosphatidyl inositol [SNOMED Notion]
- phosphatidylinositols [MeSH concept]
- phosphatidylinositols [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients