NCIt definition : A class C CpG-oligodeoxynucleotide (ODN) agonist of toll-like receptor 9 (TLR9), with
immunostimulatory, immunoadjuvant and antineoplastic activities. Upon administration,
nelitolimod targets, binds to and activates TLR9 expressed on plasmacytoid dendritic
cells (DCs), natural killer cells (NKs) and B-cells. This initiates cytokine release
from DCs and activates innate immune signaling pathways, and leads to the activation
of a cytotoxic T-lymphocyte (CTL)-mediated immune response against antigens expressed
by the tumor cells. TLR9, a member of the TLR family, plays a fundamental role in
pathogen recognition and activation of the innate immune system.;
Semantic type(s)