Preferred Label : Nelitolimod Sodium;
NCIt synonyms : SD-101 Sodium;
NCIt definition : The sodium salt form of nelitolimod, a class C CpG-oligodeoxynucleotide (ODN) agonist
of toll-like receptor 9 (TLR9), with immunostimulatory, immunoadjuvant and antineoplastic
activities. Upon administration, nelitolimod targets, binds to and activates TLR9
expressed on plasmacytoid dendritic cells (DCs), natural killer cells (NKs) and B-cells.
This initiates cytokine release from DCs and activates innate immune signaling pathways,
and leads to the activation of a cytotoxic T-lymphocyte (CTL)-mediated immune response
against antigens expressed by the tumor cells. TLR9, a member of the TLR family, plays
a fundamental role in pathogen recognition and activation of the innate immune system.;
UNII : NK22XIK2DP;
CAS number : 1263078-66-5;
NCI Metathesaurus CUI : CL1929102;
Origin ID : C206947;
concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
