NCIt definition : An orally bioavailable small molecule with potential antineoplastic activity. Thioredoxin-1
inhibitor PX-12 irreversibly binds to thioredoxin-1 (Trx-1) and inhibits its activity,
which may result in growth inhibition and the induction of apoptosis. Overexpressed
in many cancer cell types, the low molecular weight redox protein Trx-1 regulates
transcription factor activity and inhibits apoptosis, promoting cell growth and survival;
it also interacts with growth factors extracellularly to stimulate cell growth.;
Automatic exact mappings (from CISMeF team)