Preferred Label : Dactolisib;
NCIt synonyms : Benzeneacetonitrile, 4-(2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo(4,5-c)quinolin-1-yl)-alpha,alpha-dimethyl-; PI3K Inhibitor BEZ235;
NCIt definition : An orally bioavailable imidazoquinoline targeting the phosphatidylinositol 3 kinase
(PI3K) and the mammalian target of rapamycin (mTOR), with potential antineoplastic
activity. Dactolisib inhibits PI3K kinase and mTOR kinase in the PI3K/AKT/mTOR kinase
signaling pathway, which may result in tumor cell apoptosis and growth inhibition
in PI3K/mTOR-overexpressing tumor cells. Activation of the PI3K/mTOR pathway promotes
cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine
kinase downstream of PI3K, may also be activated independent of PI3K.;
UNII : RUJ6Z9Y0DT;
InChIKey : JOGKUKXHTYWRGZ-UHFFFAOYSA-N;
CAS number : 915019-65-7;
Molecule name : BEZ235; NVPBEZ235;
Origin ID : C74072;
UMLS CUI : C3501287;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
