Preferred Label : Hsp90 Inhibitor SNX-5542 Mesylate;
NCIt synonyms : SNX-5542 Mesylate;
NCIt definition : The orally bioavailable mesylate salt of a synthetic prodrug targeting the human heat-shock
protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism
of action remains to be fully elucidated, Hsp90 inhibitor SNX-5542 is rapidly converted
to SNX-2112, which accumulates in tumors relative to normal tissues. SNX-2112 inhibits
Hsp90, which may result in the proteasomal degradation of oncogenic client proteins,
including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90 is a molecular
chaperone that plays a key role in the conformational maturation of oncogenic signaling
proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many
other molecules that are important in cell cycle regulation or immune responses.;
NCI Metathesaurus CUI : CL383549;
Origin ID : C74040;
UMLS CUI : C2348997;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
