NCIt definition : An orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral
activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing
the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor
activation, which may result in decreased tumor cell proliferation and migration.
CXCR4, a chemokine receptor belonging to the GPCR (G protein-coupled receptor) gene
family, plays an important role in chemotaxis and angiogenesis and is upregulated
in several tumor cell types; it is also a co-receptor for HIV entry into T cells.;
Semantic type(s)