NCIt related terms : MK-0646; anti-IGF1R recombinant monoclonal antibody MK-0646;
NCIt definition : A recombinant humanized monoclonal antibody directed against the insulin-like growth
factor 1 receptor (IGF1R) with potential antineoplastic activity. Dalotuzumab binds
to membrane-bound IGF1R, preventing binding of the ligand IGF1 and the subsequent
triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling
pathway may result in the inhibition of tumor cell proliferation and the induction
of tumor cell apoptosis. The activation of IGF1R, a tyrosine kinase and a member of
the insulin receptor family, stimulates cell proliferation, enables oncogenic transformation,
and suppresses apoptosis; IGF1R signaling has been highly implicated in tumorigenesis
and metastasis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of many types of cancer. MK-0646
binds to a protein called insulin-like growth factor receptor (IGFR) on the surface
of cells. This may prevent the cells from growing when IGF is present. It may also
kill cancer cells. MK-0646 is a type of monoclonal antibody.;
UNII : 6YI1L648RH;
CAS number : 1005389-60-5;
Molecule name : MK-0646;
Codes from synonyms : CDR0000644752; CDR0000644753;