Dalotuzumab - CISMeF

Preferred Label : Dalotuzumab;

NCIt synonyms : Anti-IGF-1R Recombinant Monoclonal Antibody MK-0646;

NCIt related terms : MK-0646; anti-IGF1R recombinant monoclonal antibody MK-0646;

NCIt definition : A recombinant humanized monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Dalotuzumab binds to membrane-bound IGF1R, preventing binding of the ligand IGF1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. The activation of IGF1R, a tyrosine kinase and a member of the insulin receptor family, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF1R signaling has been highly implicated in tumorigenesis and metastasis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of many types of cancer. MK-0646 binds to a protein called insulin-like growth factor receptor (IGFR) on the surface of cells. This may prevent the cells from growing when IGF is present. It may also kill cancer cells. MK-0646 is a type of monoclonal antibody.;

UNII : 6YI1L648RH;

CAS number : 1005389-60-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1005389-60-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MK-0646;

Codes from synonyms : CDR0000644752; CDR0000644753;

Details

Origin ID

C74011;

UMLS CUI

C2987605;

Currated CISMeF NLP mapping
- dalotuzumab [MeSH concept]
- dalotuzumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- dalotuzumab [MeSH Supplementary Concept]
- dalotuzumab [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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