" /> Phenobarbital - CISMeF





Preferred Label : Phenobarbital;

NCIt synonyms : 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; PHENO;

NCIt definition : A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.;

Alternative definition : NCI-GLOSS: A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates.;

UNII : YQE403BP4D;

InChIKey : DDBREPKUVSBGFI-UHFFFAOYSA-N;

CAS number : 50-06-6;

Chemical formula : C12H12N2O3;

NSC code : 9848; 128143;

ChEBI ID : CHEBI:8069;

Codes from synonyms : 00018; CDR0000045470;

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01/05/2025


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