Pibrozelesin Hydrobromide

Preferred Label : Pibrozelesin Hydrobromide;

NCIt definition : The hydrobromide salt form of pibrozelesin, a semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2, with antineoplastic activity. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.;

UNII : 0481JCC90T;

InChIKey : YMALQNICPSISCA-GMUIIQOCSA-N;

CAS number : 148778-32-9;

Chemical formula : C32H36BrN5O8.BrH;

Details

Origin ID

C73816;

UMLS CUI

C2347514;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Pibrozelesin [NCIt concept]
is_salt_form_of
- Pibrozelesin [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients