Preferred Label : Pibrozelesin Hydrobromide;
NCIt definition : The hydrobromide salt form of pibrozelesin, a semisynthetic water-soluble derivative
of the antineoplastic antibiotic duocarmycin B2, with antineoplastic activity. Activated
by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich
sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing
apoptosis.;
UNII : 0481JCC90T;
InChIKey : YMALQNICPSISCA-GMUIIQOCSA-N;
CAS number : 148778-32-9;
Chemical formula : C32H36BrN5O8.BrH;
Origin ID : C73816;
UMLS CUI : C2347514;
Semantic type(s)
- concept_is_in_subset
