Preferred Label : Pibrozelesin;
NCIt synonyms : Duocamycin B2 Analog; Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic Acid, 8-(bromomethyl)-3,6,7,8-tetrahydro-2-methy-4-(((4-methyl-1-piperazinyl)carbonyl)oxy)-6-((5,6,7,-trimethoxy-1H-indol-2-yl)carbonyl)-,
Methyl Ester (S); KW 2189;
NCIt related terms : KW2189;
NCIt definition : A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin
B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine
(A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication
and inducing apoptosis.;
Alternative definition : NCI-GLOSS: A semisynthetic anticancer drug that is a type of antitumor antibiotic.;
UNII : IHK933KCIC;
CAS number : 154889-68-6;
Molecule name : KW 2189; KW-2189;
Chemical formula : C32H36BrN5O8;
Codes from synonyms : CDR0000046042;
Origin ID : C1542;
UMLS CUI : C2347513;
Automatic exact mappings (from CISMeF team)
- KW 2189 [MeSH Supplementary Concept]
- Semantic type(s)
- concept_is_in_subset
