Histone-Lysine N-Methyltransferase H3 Lysine-79 Specific

Preferred Label : Histone-Lysine N-Methyltransferase H3 Lysine-79 Specific;

NCIt synonyms : Lysine N-Methyltransferase 4; EC 2.1.1.43; DOT1-Like Protein; H3-K79-HMTase; K79 Methyltransferase; Histone H3 Methyltransferase DOT1-Like; Histone H3-K79 Methyltransferase; Histone Methyltransferase DOT1L; DOT1L;

NCIt definition : Histone-lysine N-methyltransferase, H3 lysine-79 specific (1379 aa, 185 kDa) is encoded by the human DOT1L gene. This soluble, nuclear protein may play a role in activating or repressing transcription by RNA polymerase II.;

Details

Origin ID

C73703;

UMLS CUI

C1176019;

OMIM relation
- Dot1-like [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DOT1L protein, human [MeSH concept]
- DOT1L protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DOT1L Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysine Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Gene Expression [NCIt concept]
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]
is_target
- Pinometostat [NCIt concept]

Keyword's position in hierarchy(ies) :

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