Histone-Lysine N-Methyltransferase SUV39H1

Preferred Label : Histone-Lysine N-Methyltransferase SUV39H1;

NCIt synonyms : Su(var)3-9 homolog 1; EC 2.1.1.43; H3-K9-HMTase 1; Position-effect variegation 3-9 homolog; Lysine N-methyltransferase 1A; Suv3-9h1; Suppressor of variegation 3-9 homolog 1; Histone Lysine N-Methyltransferase SUV39H1;

NCIt definition : Histone-lysine N-methyltransferase SUV39H1 (412 aa, 48 kDa) is encoded by the human SUV39H1 gene. This soluble, nuclear protein plays a role in establishment of constitutive heterochromatin at pericentric and telomeric regions. Trimethylation of H3K9 is also required to direct DNA methylation at pericentric repeats.;

Details

Origin ID

C73701;

UMLS CUI

C0914122;

OMIM relation
- Suppressor of variegation 3-9, drosophila, homolog of, 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- SUV39H1 protein, human [MeSH concept]
- SUV39H1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- SUV39H1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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