Chromobox Protein Homolog 5

Preferred Label : Chromobox Protein Homolog 5;

NCIt synonyms : Heterochromatin protein 1 homolog alpha; Antigen p25; HP1 Alpha; CBX5;

NCIt definition : Chromobox protein homolog 5 (191 aa, 22 kDa) is encoded by the human CBX5 gene. This soluble, nuclear protein plays a role in epigenetic modification of chromatin, by catalyzing the monomethylation of lysine 5 of histone H2B. The outcome of this modification is associated with either activated gene transcription, or, if further processed to trimethylated lysine 5, epigenetically repressed gene transcription. By affecting the balance of chromatin in heterochromatin and euchromatin at specific gene loci, this protein acts as a candidate tumor suppressor.;

Details

Origin ID

C73685;

UMLS CUI

C2347769;

OMIM relation
- Chromobox 5 [OMIM gene]
See also inter- (CISMeF)
- Chromobox 5 [OMIM gene]
- Chromobox Protein Homolog 5 [MeSH concept]
- Chromobox Protein Homolog 5 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- CBX5 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_chemical_classification
- Heterochromatin Protein 1 [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Aurora B Signaling Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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