Varenicline - CISMeF

Preferred Label : Varenicline;

NCIt synonyms : 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutqanedioate;

NCIt related terms : Chantix;

NCIt definition : A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself.;

Alternative definition : NCI-GLOSS: A drug used to help people stop smoking by acting the same way nicotine acts in the brain. It is a type of nicotine receptor partial agonist.;

UNII : W6HS99O8ZO;

InChIKey : JQSHBVHOMNKWFT-DTORHVGOSA-N;

CAS number : 249296-44-4;

Drug name : Champix;

Molecule name : CP-526555;

Chemical formula : C13H13N3;

Codes from synonyms : CDR0000559083;

Details

Origin ID

C73609;

UMLS CUI

C1569608;

Automatic exact mappings (from CISMeF team)
- chantix [MeSH concept]
CISMeF manual mappings
- Varenicline [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing varenicline (medicinal product) [SNOMED CT concept]
- Varenicline [MeSH Descriptor]
- Varenicline [Substance BNPC]
- Varenicline (substance) [SNOMED CT concept]
- varenicline [ATC Code]
- varenicline [ATC Code]
- varenicline [MeSH concept]
Validated automatic mappings to BTNT
- varenicline [ATC Code]
- varenicline [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Varenicline Tartrate [NCIt concept]
is_free_acid_or_base_form_of
- Varenicline Tartrate [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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