Sodium Dichloroacetate

Preferred Label : Sodium Dichloroacetate;

NCIt synonyms : Dichloroacetic Acid, Sodium Salt;

NCIt definition : The sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting in the inhibition of glycolysis and a decrease in lactate production. This agent may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling.;

UNII : 42932X67B5;

InChIKey : LUPNKHXLFSSUGS-UHFFFAOYSA-M;

CAS number : 2156-56-1;

Molecule name : CPC 211;

Chemical formula : C2HCl2O2.Na;

Details

Origin ID

C73591;

UMLS CUI

C0037501;

Automatic exact mappings (from CISMeF team)
- dichloroacetic acid [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Pyruvate Dehydrogenase Kinase [NCIt concept]

Keyword's position in hierarchy(ies) :

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