Preferred Label : Pentoxifylline;
NCIt synonyms : Oxpentifylline; Pentoxyphylline; 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione; PTX;
NCIt definition : A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline
inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate
(cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation,
improves erythrocyte flexibility, and enhances blood flow. In addition, the increased
level of cAMP in platelets inhibits platelet aggregation, which may contribute to
a reduction in blood viscosity. This agent also inhibits production of tumor necrosis
factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine
production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune
responses.;
Alternative definition : NCI-GLOSS: A drug used to prevent blood clotting and as a treatment that may help
decrease weight loss in people with cancer.;
UNII : SD6QCT3TSU;
InChIKey : BYPFEZZEUUWMEJ-UHFFFAOYSA-N;
CAS number : 6493-05-6;
Drug name : Trental;
Chemical formula : C13H18N4O3;
NSC code : 637086;
Codes from synonyms : 09091; CDR0000045369;
Origin ID : C733;
UMLS CUI : C0030899;
Automatic exact mappings (from CISMeF team)
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
