Preferred Label : Fingolimod Hydrochloride;
NCIt synonyms : 2-Amino-2-[2-(4-octylphenyl)ethyl]propan-1,3-diol Hydrochloride;
NCIt definition : The hydrochloride salt form of fingolimod, an orally available derivate of myriocin
and sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) modulator, with potential anti-inflammatory
and immunomodulating activities. Upon oral administration, fingolimod, as a structural
analogue of sphingosine, selectively targets and binds to S1PR1 on lymphocytes and
causes transient receptor activation followed by S1PR1 internalization and degradation.
This results in the sequestration of lymphocytes in lymph nodes. By preventing egress
of lymphocytes. fingolimod reduces both the amount of circulating peripheral lymphocytes
and the infiltration of lymphocytes into target tissues. This prevents a lymphocyte-mediated
immune response and may reduce inflammation. S1PR1, a G-protein coupled receptor,
plays a key role in lymphocyte migration from lymphoid tissues. Fingolimod also shifts
macrophages to an anti-inflammatory M2 phenotype, and modulates their proliferation,
morphology, and cytokine release via inhibition of the transient receptor potential
cation channel, subfamily M, member 7 (TRPM7).;
UNII : G926EC510T;
InChIKey : SWZTYAVBMYWFGS-UHFFFAOYSA-N;
CAS number : 162359-56-0;
Drug name : Gilenya;
Molecule name : FTY-720;
Chemical formula : C19H33NO2.HCl;
ChEBI ID : CHEBI:63112;
Origin ID : C72782;
UMLS CUI : C0388087;
CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
