NCIt definition : The sodium salt form of efaproxiral, a propanoic acid and allosteric modifier of hemoglobin,
with radiosensitizing activity. Efaproxiral binds non-covalently to the hemoglobin
tetramer, thereby decreasing hemoglobin-oxygen binding affinity. This results in an
increase in oxygen levels in hypoxic tumor tissues; increasing tumor oxygenation reduces
tumor radioresistance.;
Semantic type(s)