Efaproxiral - CISMeF

Preferred Label : Efaproxiral;

NCIt synonyms : Efaproxyn; 2-Dacmpp; 2-(4-(((3,5-Dimethylanilino)Carbonyl)Methyl)Phenoxy)-2-Methylpropionic Acid;

NCIt related terms : RSR13;

NCIt definition : A synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. (NCI04);

Alternative definition : NCI-GLOSS: A drug that may increase the effectiveness of radiation therapy.;

NCIt note : 5-11-04 FDA advisory committee advised not to approve;

UNII : J81E81G364;

InChIKey : BNFRJXLZYUTIII-UHFFFAOYSA-N;

CAS number : 131179-95-8;

Molecule name : RSR-13;

Chemical formula : C20H23NO4;

NSC code : 950116;

Codes from synonyms : CDR0000045527; CDR0000269877;

Details

Origin ID

C1435;

UMLS CUI

C0080719;

Automatic exact mappings (from CISMeF team)
- Efaproxiral [ICD-11 Extension code]
Currated CISMeF NLP mapping
- efaproxiral [MeSH concept]
- efaproxiral [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- efaproxiral [ATC Code]
- efaproxiral [MeSH Supplementary Concept]
- efaproxiral [MeSH concept]
Validated automatic mappings to BTNT
- efaproxiral [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Carmustine/Efaproxiral [NCIt concept]
- Carmustine/RSR13 [NCIt concept]

Keyword's position in hierarchy(ies) :

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