" /> Ambrisentan - CISMeF





Preferred Label : Ambrisentan;

NCIt synonyms : ( -)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic Acid;

NCIt definition : An orally bioavailable, selective antagonist of the endothelin type-A (ETA) receptor that may be used for the treatment of pulmonary arterial hypertension (PAH). Upon administration, ambrisentan targets and binds to ETA receptor, which prevents the binding of endothelin-1 (ET-1) to the ETA receptor and ET-1/ETA-mediated vasoconstriction and cell proliferation. This may lead to vasodilation. ET-1 concentrations are increased in plasma as well as lung tissue in PAH, and ET-1 may play a key role in the pathogenesis of PAH.;

UNII : HW6NV07QEC;

InChIKey : OUJTZYPIHDYQMC-LJQANCHMSA-N;

CAS number : 177036-94-1;

Drug name : Letairis; Pulmonext; Volibris;

Molecule name : BSF-208075; LU-208075;

Chemical formula : C22H22N2O4;

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04/05/2025


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