Linifanib - CISMeF

Preferred Label : Linifanib;

NCIt synonyms : Receptor Tyrosine Kinase Inhibitor ABT-869;

NCIt related terms : multitargeted receptor tyrosine kinase inhibitor ABT-869; ABT-869;

NCIt definition : An orally bioavailable receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3).;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer. ABT-869 blocks the action of several growth factors. It may also block the growth of new blood vessels that tumors need to grow and may cause cancer cells to die. It is a type of receptor tyrosine kinase inhibitor and a type of angiogensis inhibitor.;

UNII : CO93X137CW;

InChIKey : MPVGZUGXCQEXTM-UHFFFAOYSA-N;

CAS number : 796967-16-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 796967-16-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ABT-869;

Chemical formula : C21H18FN5O;

Codes from synonyms : CDR0000641978; CDR0000641976;

Details

Origin ID

C71759;

UMLS CUI

C1737951;

Currated CISMeF NLP mapping
- linifanib [MeSH concept]
See also inter- (CISMeF)
- linifanib [MeSH concept]
- linifanib [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- linifanib [MeSH concept]
- linifanib [MeSH Supplementary Concept]
- linifanib [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients