Apatorsen - CISMeF

Preferred Label : Apatorsen;

NCIt synonyms : Hsp27 Antisense Oligonucleotide OGX-427;

NCIt definition : A second-generation antisense oligonucleotide targeting heat shock protein 27 (Hsp27) with potential antitumor and chemosensitizing activities. Apatorsen suppresses tumor cell expression of Hsp27, which may induce tumor cell apoptosis and enhance tumor cell sensitivity to cytotoxic agents. Hsp27, a chaperone belonging to the small heat shock protein (sHsp) group of proteins, is a cytoprotective protein that supports cell survival under conditions of stress; it has been found to be over-expressed in a variety of human cancers.;

UNII : IFJ6X26JW6;

CAS number : 1002331-21-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1002331-21-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : OGX-427; ISIS 306053;

Details

Origin ID

C71740;

UMLS CUI

C4055447;

Automatic exact mappings (from CISMeF team)
- apatorsen [MeSH Supplementary Concept]
- apatorsen [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- apatorsen [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Heat Shock Protein Beta-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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