NCIt synonyms : PI3K Family Kinase Inhibitor XL147; 2-Amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide;
NCIt definition : An orally bioavailable small molecule, targeting the class I phosphatidylinositol
3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Pilaralisib
reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production
of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation
of the PI3K signaling pathway; this may result in inhibition of tumor cell growth
and survival in susceptible tumor cell populations. Activation of the PI3K signaling
pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may
contribute to tumor resistance to a variety of antineoplastic agents including genotoxic
agents and receptor tyrosine kinase inhibitors.;
Currated CISMeF NLP mapping