Pioglitazone - CISMeF

Preferred Label : Pioglitazone;

NCIt synonyms : Pioglitazone Base;

NCIt definition : An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.;

Alternative definition : NCI-GLOSS: A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione.;

UNII : X4OV71U42S;

InChIKey : HYAFETHFCAUJAY-UHFFFAOYSA-N;

CAS number : 111025-46-8;

Chemical formula : C19H20N2O3S;

ChEBI ID : CHEBI:8228;

Codes from synonyms : CDR0000410212;

Details

Origin ID

C71633;

UMLS CUI

C0071097;

Currated CISMeF NLP mapping
- Pioglitazone [MeSH Descriptor]
- Pioglitazone [LOINC component]
- Pioglitazone [ICD-11 Extension code]
- Pioglitazone (substance) [SNOMED CT concept]
- Product containing pioglitazone (medicinal product) [SNOMED CT concept]
- pioglitazone [Substance BNPC]
- pioglitazone [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pioglitazone [MeSH Descriptor]
- Pioglitazone [LOINC component]
- Pioglitazone (substance) [SNOMED CT concept]
- Product containing pioglitazone (medicinal product) [SNOMED CT concept]
- pioglitazone [ATC Code]
- pioglitazone [Substance BNPC]
- pioglitazone [MeSH concept]
Validated automatic mappings to BTNT
- pioglitazone [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Pioglitazone Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Pioglitazone Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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