" /> Pioglitazone Hydrochloride - CISMeF





Preferred Label : Pioglitazone Hydrochloride;

NCIt synonyms : Pioglitazone;

NCIt related terms : Actos; Pioglitazone.HCl;

NCIt definition : The hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI05);

Alternative definition : NCI-GLOSS: A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione.;

UNII : JQT35NPK6C;

InChIKey : GHUUBYQTCDQWRA-UHFFFAOYSA-N;

CAS number : 112529-15-4;

Drug name : Actos;

Chemical formula : C19H20N2O3S.HCl;

Codes from synonyms : CDR0000413938; 20324;

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09/05/2025


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