Biricodar - CISMeF

Preferred Label : Biricodar;

NCIt definition : A pipecolinate derivative. Functioning as a modulator of P-glycoprotein (P-gp) and multidrug resistance protein (MRP-1), biricodar restores drug sensitivity to cells expressing P-glycoprotein and MRP1, the cellular efflux pumps that are the major causes in tumor cell resistance to chemotherapeutic agents. This agent binds directly to Pgp and MRP-1 and inhibits efflux pump activity, resulting in increased intracellular accumulation and retention of cytotoxic agents.;

UNII : 3KG76X4KJK;

InChIKey : CGVWPQOFHSAKRR-NDEPHWFRSA-N;

CAS number : 159997-94-1;

Molecule name : VX-710;

Chemical formula : C34H41N3O7;

Details

Origin ID

C71621;

UMLS CUI

C0754576;

Automatic exact mappings (from CISMeF team)
- biricodar [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- biricodar [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- biricodar [MeSH concept]
- biricodar [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Biricodar Dicitrate [NCIt concept]
is_free_acid_or_base_form_of
- Biricodar Dicitrate [NCIt concept]

Keyword's position in hierarchy(ies) :

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