NCIt definition : The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing
activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein
(P-gp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which
may result in increased intracellular accumulation and retention of cytotoxic agents.;
Alternative definition : NCI-GLOSS: A drug being studied to make cancer cells less resistant to the effects
of chemotherapy.;