NCIt definition : A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits
the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid
tryptophan, and may increase or maintain tryptophan levels important to T cell function.
Tryptophan depletion is associated with immunosuppression involving T cell arrest
and anergy.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of melanoma and many other types
of cancer. 1-methyl-d-tryptophan blocks the breakdown of the amino acid tryptophan,
which is needed for T cells (a type of immune system cell) to kill tumor cells. Giving
1-methyl-d-tryptophan to patients who have received chemotherapy for cancer may help
kill more tumor cells. It is a type of enzyme inhibitor and immunosuppressant.;
UNII : TX5CYN1KMZ;
InChIKey : ZADWXFSZEAPBJS-SNVBAGLBSA-N;
CAS number : 110117-83-4;
Codes from synonyms : CDR0000599989; CDR0000599960;
Automatic exact mappings (from CISMeF team)