" /> Ganitumab - CISMeF





Preferred Label : Ganitumab;

NCIt synonyms : Anti-IGF-1R Human Monoclonal Antibody AMG-479;

NCIt definition : A recombinant, fully human monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Ganitumab binds to membrane-bound IGF-1R, preventing binding of the ligand IGF-1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a tyrosine kinase and a member of the insulin receptor family. IGF-1R activation stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been highly implicated in tumorigenesis and metastasis.;

UNII : CK1441RCZ8;

CAS number : 905703-97-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 905703-97-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AMG 479;

Codes from synonyms : 241;

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12/05/2024


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