NCIt definition : A recombinant, human monoclonal antibody directed against the insulin-like growth
factor 1 receptor (IGF-1R) with potential antineoplastic activity. Anti-IGF-1R recombinant
monoclonal antibody BIIB022 binds to membrane-bound IGF-1R, preventing binding of
the ligand IGF-1 and the subsequent triggering of the PI3K/Akt signaling pathway;
inhibition of this survival signaling pathway may result in the inhibition of tumor
cell proliferation and the induction of tumor cell apoptosis. The activation of IGF-1R,
a tyrosine kinase and a member of the insulin receptor family, stimulates cell proliferation,
enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been
highly implicated in tumorigenesis and metastasis.;
UNII : Y60655Y65T;
CAS number : 1242567-19-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1242567-19-6
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