Preferred Label : Tanezumab;
NCIt synonyms : Anti-NGF Monoclonal Antibody RN624;
NCIt definition : A humanized monoclonal antibody directed against nerve growth factor (NGF), a modulator
of nociceptor function, with potential analgesic activity. Tanezumab binds to NGF
and prevents NGF binding to its high affinity, membrane-bound, catalytic receptor
tropomyosin-related kinase A (TrkA), which is present on sympathetic and sensory neurons;
reduced stimulation of TrkA by NGF inhibits the pain-transmission activities of these
neurons. NGF, a neurotrophin, is critical to the growth and maintenance of sympathetic
and sensory neurons. In addition, NGF may induce mast cells to release inflammatory
proteins and may induce the upregulation of substance P and other pain-related peptides
in sympathetic and sensory neurons. Upon neurotrophin binding, TrkA phosphorylates
itself and members of the MAPK pathway, mediating the multiple neuronal effects of
NGF.;
UNII : EQL0E9GCX1;
CAS number : 880266-57-9;
Molecule name : PF-4383119; RN624;
Origin ID : C71522;
UMLS CUI : C2346819;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
