NCIt synonyms : Anti-PD-1 Monoclonal Antibody CT-011; Immunoglobulin G1, Anti-(Human Programmed Cell Death 1); Humanized Mouse Monoclonal
CT-011 Gamma1 Heavy Chain (220-213')-disulfide with Humanized Mouse Monoclonal CT-011
Kappa Light Chain Dimer (226-226'':229-229'')-bisdisulfide, Glycosylated (CT-011 is
Expressed in NSO Cells);
NCIt definition : A humanized monoclonal antibody directed against human PD-1 (programmed cell death
1; PDCD1), with immunomodulating and antitumor activities. Pidilizumab blocks interaction
between the receptor PD-1 with its ligands, PD-1 ligand 1 (PD-1L1) and PD-1 ligand
2 (PD-1L2), resulting in the attenuation of apoptotic processes in lymphocytes, primarily
effector/memory T cells, and the augmentation of the anti-tumor activities of NK cells.
PD-1 is an inhibitory receptor belonging to the B7-receptor family that is expressed
on lymphocytes and myeloid cells; its ligands, PD-1L1 and PD-1L2, are expressed not
only by hematopoietic cells but also by cells in non-lymphoid tissues.;