" /> Linsitinib - CISMeF





Preferred Label : Linsitinib;

NCIt synonyms : cis-3-(8-Amino-1-(2-Phenylquinolin-7-yl)Imidazo(1,5-A)Pyrazin-3-yl)-1-Methylcyclobutanol; Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl, cis-;

NCIt related terms : OSI-906; IGF-1R inhibitor OSI-906;

NCIt definition : An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks a protein called IGF-1R, which is found at high levels in some types of tumors. IGF-1R is needed for cell growth and blocking it may cause tumor cells to die. IGF-1R inhibitor OSI-906 is a type of IGF-1R inhibitor.;

UNII : 15A52GPT8T;

InChIKey : PKCDDUHJAFVJJB-VLZXCDOPSA-N;

CAS number : 867160-71-2;

Molecule name : OSI-906; OSI-906AA;

Chemical formula : C26H23N5O;

Codes from synonyms : CDR0000663299; CDR0000663300; 75494;

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07/05/2025


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