NCIt definition : A monoclonal antibody directed against the receptor-like leukocyte cell surface glycoprotein
CD45 with leukocyte-depleting activity. Upon administration, anti-CD45 monoclonal
antibody binds to leukocyte surface-expressed CD45, which may result in the transient
depletion of circulating leukocytes including circulating T cell depletion (TCD).
CD45, a receptor-like protein-tyrosine phosphatase that consists of several isoforms,
is present on all differentiated hematopoietic cells except erythrocytes and plasma
cells and is essential for T cell development and lymphocyte activation.;
Alternative definition : NCI-GLOSS: A monoclonal antibody being studied in the treatment of some types of cancer.
Monoclonal antibodies are made in the laboratory and can locate and bind to substances
in the body, including cancer cells. Anti-CD45 monoclonal antibody binds to members
of a family of proteins called CD45. Certain CD45 proteins are found on the surface
of most types of blood cells, and some types of leukemia and lymphoma cells.;
Semantic type(s)