Preferred Label : Erastin Analogue PRLX 93936;
NCIt synonyms : Erastin Analogue PRLX93936;
NCIt definition : A structural analogue of erastin with potential antineoplastic activity. Erastin analogue
PRLX 93936 appears to inhibit mitochondrial outer membrane protein VDACs (voltage-dependent
anion channels) 2 and 3, resulting in an oxidative, non-apoptotic cell death. Erastin
analogue PRLX 93936 exhibits greater lethality in cell lines harboring mutations in
the GTPase protein oncogenes HRAS and KRAS or the serine-threonine protein kinase
oncogene BRAF than in non-tumorigenic cell lines. VDACs 2 and 3 are up-regulated in
a wide variety of tumor cell lines.;
Molecule name : PRLX 93936;
NCI Metathesaurus CUI : CL375988;
PubMed : 17568748;
Origin ID : C70625;
UMLS CUI : C2348466;
Semantic type(s)
- concept_is_in_subset
- has_target
