Preferred Label : Nimodipine;

NCIt synonyms : NIMO;

NCIt definition : A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents.;

Alternative definition : NCI-GLOSS: Belongs to a family of drugs called calcium channel blockers. It is being investigated for use with anticancer drugs to prevent or overcome drug resistance and improve response to chemotherapy.;

UNII : 57WA9QZ5WH;

InChIKey : UIAGMCDKSXEBJQ-UHFFFAOYSA-N;

CAS number : 66085-59-4;

Drug name : Nimotop;

Chemical formula : C21H26N2O7;

ChEBI ID : CHEBI:7575;

Codes from synonyms : 30497; CDR0000045346;

Details


Keyword's position in hierarchy(ies) : arborescence

Main resources

You can consult :


https://www.has-sante.fr/jcms/p_3477067/fr/nimotop-nimodipine-maladie-ischemique-neurologique
2023
France
evaluation of the transparency committee
Nervous System Finding
Ischemia
No Evidence of Coronary Artery Disease
nervous system diseases
nimodipine
ischemia, nos
Nimodipine
disease
Disease Object
Disease Free
Ischemia Procedure
Disease Steps Clinical Classification
ischemia
disease, nos
nimotop
neurology
nimodipine
Nervous System

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03/07/2025


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