Nimodipine - CISMeF

Preferred Label : Nimodipine;

NCIt synonyms : NIMO;

NCIt definition : A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents.;

Alternative definition : NCI-GLOSS: Belongs to a family of drugs called calcium channel blockers. It is being investigated for use with anticancer drugs to prevent or overcome drug resistance and improve response to chemotherapy.;

UNII : 57WA9QZ5WH;

InChIKey : UIAGMCDKSXEBJQ-UHFFFAOYSA-N;

CAS number : 66085-59-4;

Drug name : Nimotop;

Chemical formula : C21H26N2O7;

ChEBI ID : CHEBI:7575;

Codes from synonyms : 30497; CDR0000045346;

Détails

Origin ID

C692;

UMLS CUI

C0028094;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nimodipine [ICD-11 Extension code]
- Nimodipine (substance) [SNOMED CT concept]
- Product containing nimodipine (medicinal product) [SNOMED CT concept]
- nimodipine [ATC Code]
- nimodipine [Substance BNPC]
- nimodipine [MeSH Descriptor]
- nimodipine [SNOMED Notion]
- nimodipine [MeSH concept]
Validated automatic mappings to BTNT
- nimodipine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Carmustine/Nimodipine/Vincristine [NCIt concept]
- Nimodipine/Vincristine [NCIt concept]

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