MEK Inhibitor AZD8330

Preferred Label : MEK Inhibitor AZD8330;

NCIt related terms : AZD-8330;

NCIt definition : An orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.;

UNII : G4990BOZ66;

CAS number : 869357-68-6;

Molecule name : AZD8330; ARRY-704; ARRY-424704;

Details

Origin ID

C69143;

UMLS CUI

C2346908;

Currated CISMeF NLP mapping
- AZD8330 [MeSH concept]
- AZD8330 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AZD8330 [MeSH Supplementary Concept]
- AZD8330 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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