Preferred Label : Hsp90 Antagonist KW-2478;
NCIt related terms : KW-2478;
NCIt definition : An agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic
activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist
KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition
of cell proliferation, and the induction of apoptosis in tumor cells. HSP90 is a molecular
chaperone that plays a key role in the conformational maturation of oncogenic signaling
proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many
other molecules that are important in cell cycle regulation or immune responses.;
UNII : E628ZH6U2C;
CAS number : 819812-18-5;
Molecule name : KW-2478;
Origin ID : C69139;
UMLS CUI : C2348995;
Semantic type(s)
- UMLS correspondences (same concept)
- KW-2478 [MeSH Supplementary Concept]
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
