" /> Apoptosis Inducer BZL101 - CISMeF





Preferred Label : Apoptosis Inducer BZL101;

NCIt related terms : SCUTELLARIA BARBATA TOP;

NCIt definition : An orally active aqueous extract derived from the plant Scutellaria barbata with potential antineoplastic activity. Sparing normal cells, apoptosis inducer BZL101 specifically facilitates translocation of the protein apoptosis-inducing factor (AIF) from the mitochondrial membrane into the nucleus in tumor cells, thereby causing tumor cell-specific chromatin condensation and DNA degradation followed by the induction of caspase-independent apoptosis. AIF is both a mitochondrial intermembrane flavoprotein with oxidoreductase activity and a caspase-independent death effector that, similar to cytochrome c, is released from mitochondria early in the apoptotic process.;

UNII : J52LXC6DTW;

Molecule name : BZL101;

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30/07/2025


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