" /> Cobimetinib - CISMeF





Preferred Label : Cobimetinib;

NCIt synonyms : MEK Inhibitor GDC-0973; MEK Inhibitor XL518;

NCIt definition : An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases.;

UNII : ER29L26N1X;

InChIKey : BSMCAPRUBJMWDF-KRWDZBQOSA-N;

CAS number : 934660-93-2;

Drug name : Cotellic;

Molecule name : GDC-0973; XL 518; XL-518; GDC 0973;

Codes from synonyms : 113;

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29/05/2025


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