Tapentadol Hydrochloride

Preferred Label : Tapentadol Hydrochloride;

NCIt synonyms : Tapentadol Hydrochloride ER; 3-((1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl)phenol Hydrochloride;

NCIt definition : The hydrochloride salt of tapentadol, an orally available, synthetic benzenoid that acts as an agonist for the mu-opioid receptor (MOR) and inhibits the reuptake of noradrenaline, with potential anti-nociceptive activity. Upon oral administration, tapentadol binds to the MOR which enhances MOR-mediated signaling, interferes with the sensation of pain and results in an analgesic effect. Tapentadol also inhibits the reuptake of noradrenaline, which increases the levels of noradrenaline (NA), activates the inhibitory alpha-2 receptors and results in an analgesic effect.;

UNII : 71204KII53;

InChIKey : ZELFLGGRLLOERW-YECZQDJWSA-N;

CAS number : 175591-09-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 175591-09-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Nucynta;

Molecule name : JNS024; CG5503 ER; R331333;

Chemical formula : C14H23NO.HCl;

Details

Origin ID

C68922;

UMLS CUI

C2710874;

See also inter- (CISMeF)
- Tapentadol hydrochloride (product) [Inactive SNOMED CT concept]
- tapentadol [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Tapentadol [MeSH Descriptor]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Tapentadol [NCIt concept]
has_target
- Mu-Type Opioid Receptor [NCIt concept]
is_salt_form_of
- Tapentadol [NCIt concept]

Keyword's position in hierarchy(ies) :

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