NCIt definition : The hydrochloride salt of tapentadol, an orally available, synthetic benzenoid that
acts as an agonist for the mu-opioid receptor (MOR) and inhibits the reuptake of noradrenaline,
with potential anti-nociceptive activity. Upon oral administration, tapentadol binds
to the MOR which enhances MOR-mediated signaling, interferes with the sensation of
pain and results in an analgesic effect. Tapentadol also inhibits the reuptake of
noradrenaline, which increases the levels of noradrenaline (NA), activates the inhibitory
alpha-2 receptors and results in an analgesic effect.;