Preferred Label : Icosapent;
NCIt synonyms : Timnodonic Acid; cis-5,8,11,14,17-Eicosapentaenoic Acid; EPA-FFA; Eicosapentaenoic Acid-Free Fatty Acid;
NCIt related terms : Icosapentaenoic Acid n-3; All-cis-icosa-5,8,11,14,17-pentaenoic acid; Fatty Acid 20:5 n-3; Eicosapentaenoic Acid n-3;
NCIt definition : The free fatty acid (FFA) form of eicosapentaenoic acid (EPA), a polyunsaturated long-chain
fatty acid found in fish oil with a 20-carbon backbone and 5 double bonds, with potential
supplementing, anti-inflammatory, anti-thrombotic, immunomodulating, anti-angiogenic
and chemopreventive activities. Upon administration of icosapent, the free form of
EPA is incorporated in cell membrane phospholipids and replaces arachidonic acid.
This inhibits arachidonic acid conversion into thromboxanes and prostaglandin E2 (PGE2).
Upon oral administration of icosapent, the EPA-FFA prevents and suppresses colonic
neoplasia and reduces polyp formation and growth through as of yet not fully elucidated
mechanisms.;
Alternative definition : CRCH: Polyunsaturated fatty acid with 20 carbons and 5 double bonds at the 3rd, 6th,
9th, 12th and 15th carbons from the methyl end.;
UNII : AAN7QOV9EA;
InChIKey : JAZBEHYOTPTENJ-JLNKQSITSA-N;
CAS number : 10417-94-4; 25377-48-4;
Unit used : g;
Chemical formula : C20H30O2;
ChEBI ID : CHEBI:28364;
Origin ID : C68434;
UMLS CUI : C0000545;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
