Neomycin - CISMeF

Preferred Label : Neomycin;

NCIt synonyms : Neomycin Complex;

NCIt definition : A broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.;

UNII : I16QD7X297;

CAS number : 1404-04-2;

ChEBI ID : CHEBI:7507;

Codes from synonyms : 31674;

Details

Origin ID

C683;

UMLS CUI

C0027603;

Automatic exact mappings (from CISMeF team)
- Neomycin (derivatives) [ICHI extension code]
- framycetin [MeSH Descriptor]
- framycetin [Substance BNPC]
- neamine [MeSH Supplementary Concept]
- neomycin b [SNOMED Notion]
- neomycin c [SNOMED Notion]
- paromomycin [MeSH Descriptor]
- paromomycin [Substance BNPC]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Neomycin [LOINC component]
- Neomycin (substance) [SNOMED CT concept]
- Product containing neomycin (medicinal product) [SNOMED CT concept]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [Substance BNPC]
- neomycin [MeSH Descriptor]
- neomycin [SNOMED Notion]
- neomycin [MeSH concept]
Validated automatic mappings to BTNT
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
- neomycin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Neomycin Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Neomycin Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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