Neomycin Sulfate

Preferred Label : Neomycin Sulfate;

NCIt definition : The sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.;

UNII : 057Y626693;

CAS number : 1405-10-3;

ChEBI ID : CHEBI:31635;

Details

Origin ID

C66227;

UMLS CUI

C0027607;

Automatic exact mappings (from CISMeF team)
- neomycin [MeSH Descriptor]
See also inter- (CISMeF)
- neomycin sulfate allergic contact dermatitis [DO Concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
Validated automatic mappings to NTBT
- neomycin [MeSH Descriptor]
- neomycin [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Neomycin [NCIt concept]
is_salt_form_of
- Neomycin [NCIt concept]

Keyword's position in hierarchy(ies) :

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