Zinostatin - CISMeF

Preferred Label : Zinostatin;

NCIt synonyms : Neocarzinostatin; Vinostatin; NCS; Holoneocarzinostatin;

NCIt definition : An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. (NCI04);

UNII : PP082U6W1L;

CAS number : 9014-02-2;

Molecule name : A 8544527G1;

Chemical formula : C35H35NO12;

NSC code : 69856; 157365;

PubMed : 20735485;

Details

Origin ID

C682;

UMLS CUI

C0027597;

Automatic exact mappings (from CISMeF team)
- Zinostatin [ICHI extension code]
Currated CISMeF NLP mapping
- Zinostatin [ICD-11 Extension code]
- zinostatin [MeSH Descriptor]
- zinostatin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Zinostatin [ICD-11 Extension code]
- zinostatin [MeSH Descriptor]
- zinostatin [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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