Remestemcel-L - CISMeF

Preferred Label : Remestemcel-L;

NCIt synonyms : Allogeneic Adult Mesenchymal Stem Cells; Allogeneic Adults MSCs; Allogeneic Expanded Mesenchymal Stem Cells;

NCIt definition : Human mesenchymal stem cells (MSCs) harvested from bone marrow of healthy adult donors and expanded ex vivo, with potential immunosuppressive application. Allogeneic adult MSCs are hypo-immunogenic due to lack of major histocompatibility II (MHC II) molecule expression, and thereby elicit none or minimal immune response upon intravenous infusion. MSCs are pluripotent, and are capable of being recruited to damaged tissue sites and differentiating along specific lineages when stimulated. Infusion of MSCs results in: a) increased production of anti-inflammatory cytokines, such as interleukin-10, prostaglandin E, and hepatocyte growth factor; b) decreased mononuclear phagocyte expression of indoleamine 2,3,-dioxygenase, which catabolizes L-tryptophan into its metabolites, which in turn contribute to inflammation; and c) modulated dendritic cell maturation and disrupted activities of natural killer cells, CD8 and CD4 T cells.;

UNII : H57D26Z9YK;

Drug name : Prochymal;

Molecule name : JR-0301;

Details

Origin ID

C67082;

UMLS CUI

C1879680;

Currated CISMeF NLP mapping
- remestemcel-l [MeSH concept]
- remestemcel-l [MeSH Supplementary Concept]
Semantic type(s)
- Cell [UMLS semantic type]
UMLS correspondences (same concept)
- remestemcel-l [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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