Human Lactoferrin Peptide hLF1-11

Preferred Label : Human Lactoferrin Peptide hLF1-11;

NCIt synonyms : Human Lactoferrin 1-11 Peptide;

NCIt related terms : HLF(1-11);

NCIt definition : A synthetic peptide corresponding to the first 11 N-terminal amino acids of human lactoferrin (hLF1-11) with potential antimicrobial activity. Human lactoferrin, a 692 amino acid glycoprotein belonging to the transferrin family of metal-binding proteins, can be found in milk and other secretory fluids as well as in polymorphonuclear cells and leukocytes. Human lactoferrin plays a role in the innate defense of mucosal surfaces and neutrophils. Although the exact mechanism through which this peptide exerts its effect has yet to be fully elucidated, hLF1-11 may seize iron, thereby limiting the availability of free iron for microorganisms in the body. hLF1-11 appears to be effective against a variety of bacteria and fungi, including the multidrug-resistant Acinetobacter baumannii, multidrug-resistant Staphylococcus aureus, and fluconazole-resistant Candida albicans strains.;

UNII : 72YOI2Q5AK;

CAS number : 183623-03-2;

Details

Origin ID

C67046;

UMLS CUI

C1144139;

Automatic exact mappings (from CISMeF team)
- lactoferrin (1-11), human [MeSH concept]
- lactoferrin (1-11), human [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- lactoferrin (1-11), human [MeSH concept]
- lactoferrin (1-11), human [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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