MDR Modulator CBT-1

Preferred Label : MDR Modulator CBT-1;

NCIt synonyms : CBT-1;

NCIt definition : A naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant tumors.;

Alternative definition : NCI-GLOSS: A substance taken from plants that is being studied in the treatment of cancer. It may help drugs kill tumor cells that have become resistant to drugs. It is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.;

Codes from synonyms : CDR0000630970; CDR0000630969;

Détails

Origin ID

C67042;

UMLS CUI

C0916470;

Automatic exact mappings (from CISMeF team)
- Pheochromocytoma/paraganglioma syndrome 1 [OMIM Phenotype]
Currated CISMeF NLP mapping
- CBT-1 (plant alkaloid) [MeSH concept]
- CBT-1 (plant alkaloid) [MeSH Supplementary Concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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