NCIt definition : A naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with
potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the
MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic
agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane
ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant
tumors.;
Alternative definition : NCI-GLOSS: A substance taken from plants that is being studied in the treatment of
cancer. It may help drugs kill tumor cells that have become resistant to drugs. It
is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.;
Codes from synonyms : CDR0000630970; CDR0000630969;
Automatic exact mappings (from CISMeF team)